马克Schramp
类 | 教育 | 研究 | 出版物 | 演讲 | 哥伦布发现美洲纪念日
类
- Principles of 生物学
- General 生物学 I
- 微生物学
- Molecular and Cell 生物学
- Developmental 生物学
教育
Ph. D.
Molecular and Cell 生物学
University of California, Berkeley
Bachelor of Science
生物学
Marquette University
Research Interests
We are studying how epithelial cells adopt specific characteristics that allow them to function within an organ system. Epithelial cells line the exterior of most organs and are therefore essential for development and normal homeostasis. During development of an organ, cells must respond to signals that direct them to alter their behavior (i.e. movement/migration, division and differentiation). How a cell integrates and responds to these signals is essential to form a functional organ. 在我们的实验室, we use the model organism Caenorhabditis 线虫 to study how specific proteins regulate epithelial cell behavior during development. 特别是, we are interested in how epithelial cells adhere to one another and to different protein matrices in their environment and how these connections are regulated during normal organogenesis. We have identified a number of important proteins (including the putative tumor suppressor protein, TES-1) that help epithelial cells move, form strong adhesions with other cells and their environment and adopt unique shapes that allow them to function within an organ. Our research can not only lead us to a deeper understanding of development, but can also shed light on how specific diseases arise. 例如, tumors that arise from epithelial cells constitute over 80% of the malignancies diagnosed each year. The ability of a tumor to form metastases, secondary tumors that enhance the lethality of the disease, depends on the same protein machinery that regulates normal cellular movement, migration and adhesion.
出版物
马克Schramp, Lynch A and Hardin J (2012). TES-1 regulates cell adhesion during epithelial morphogenesis in C. 线虫. (In preparation).
马克Schramp and Jeff Hardin (2011). Tissue Remodeling: Making Way for Cellular Invaders. 当代生物学, 21 (15):R585-7.
马克Schramp, Hedman A, Li W, Tan X and Anderson R (2011). PIP kinases from the cell membrane to the nucleus. 亚晶胞物化学. 2012;58:25-59.
Thapa N, 马克Schramp, Choi S, Ling K and Anderson R (2010). PIPKIγi2 modulates the exocyst complex to regulate recruitment of integrin molecules in directionally migrating cells. Developmental Cell. 22(1):116-30
马克Schramp, Thapa N, Heck J and Anderson R (2010). PIPKIγ regulates β-catenin transcriptional activity in mesenchymal-like cells downstream of growth factor receptor activation. 癌症研究, 15;71(4):1282-91.
Schill, N, Hedman A, Choi S, 马克Schramp and Anderson R (2010). PIPKIγi5 induces E-cadherin degradation by enhancing its trafficking to the lysosome. (In Preparation).
马克Schramp, Olivia Ying*, T.Y. 金和G. Steven Martin (2008). ERK5 Promotes Src-induced Podosome Formation by limiting Rho activation. Journal of Cell 生物学, 181(7):1195-1210.
Jia L, Dienhart M, Schramp米, McCauley M, Hell K and Stuart RA (2003). Yeast Oxa1 interacts with mitochondrial ribosomes: the importance of the C-terminal region of Oxa1. EMBO J. 22 (24): 6438-47.
Abstracts / Presentations
马克·W. Schramp, Lynch A and Hardin J (2011). TES-1 mediates epithelial morphogenesis.
18th International C. 线虫的会议. 加州大学洛杉矶分校. Poster Presentation.
马克Schramp, Lim PY, Gardner J, Yu J. Engaging 微生物学 Students in a Lesson on Human-Microbial Symbioses. Teaching and Learning Symposium. University of Wisconsin. Poster Presentation.
马克Schramp, Thapa N, Heck J, Turbin D, Huntsman D and Anderson R (2010). PIPKIγ regulates β-catenin transcriptional activity in mesenchymal-like cells downstream of growth factor receptor activation. Signal Transduction Research Training Symposium. University of Wisconsin. Poster Presentation.
马克Schramp, Ying O* and Martin GS (2008). ERK5 Promotes Src-induced Podosome Formation by limiting Rho activation. American Association for 癌症研究: Cytoskeleton Signaling in Cancer. Poster Presentation
马克Schramp, Olivia Ying* and G. Steven Martin (2007). ERK5 Activity is Required for Src-induced Podosome formation. Mechanisms and Models of Cancer. 索尔克研究所. Poster Presentation.
* Denotes mentored undergraduate
Discovery Day Projects
Expression pattern and sub-cellular localization of TES-1 and UNC-34 during epithelial morphogenesis – Kevin Amthor, 尼克Loughman
Effects of TES-1 and UNC-34 proteins on the Behavior of Epithelial Cells – Rachel Foguth